Spatial and temporal variations in atmospheric carbon dioxide Hardware (CO2) reflect large-scale net carbon exchange between the atmosphere and terrestrial ecosystems.Soil heterotrophic respiration (HR) is one of the component fluxes that drive this net exchange, but, given observational limitations, it is difficult to quantify this flux or to eval
A novel CRISPR/Cas9-based iduronate-2-sulfatase (IDS) knockout human neuronal cell line reveals earliest pathological changes
Abstract Multiple complex intracellular cascades contributing to Hunter syndrome (mucopolysaccharidosis type II) pathogenesis have been recognized and documented in the past years.However, the hierarchy of early cellular abnormalities leading to irreversible neuronal damage is far from being completely understood.To tackle Lunge Lines this issue, w
Challenges relating to the inter-facility transport of high acuity paediatric cases
Introduction: The motivation for this study came from anecdotal reports and observations that there was a potential need for improvement to the systems that support inter-facility transfers of high acuity paediatric cases between referring and receiving facilities in Johannesburg, South Africa.In this exploratory study, we formally document and des
Optimalisasi Manajemen Pencegahan Dan Penanggulangan Kebakaran Di Kota Bandung
The performance of the Regional Government of Bandung City in preventing and taking care of Baskets fire is still being questioned as it is noted that during the last five years there have been 4 to 6 blazes a day.The author sees that in some aspects the fire service is lacking, such as in the aspects of institutional, funding, mapping, and coordin
GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
A stress adaptation pathway termed the integrated stress response has been suggested to be active in many cancers including prostate cancer (PCa).Here, we demonstrate that the eIF2 kinase GCN2 is required for sustained growth in androgen-sensitive and castration-resistant models of PCa both in Creamers vitro and in vivo, and is active in PCa patien